Analysis of Volatile Emissions from Polymers and Paperboard
This webinar describes a recent addition to the portfolio of techniques available for routine sample analysis: SIFT-MS. SIFT-MS enables rapid, quantitative analysis of VOCs across the full spectrum of packaging materials. Detailed case studies will describe applications in polymeric and paperboard emissions analysis.
Routine Analysis 3: SIFT-MS Method Development and Validation
In this webinar, we discuss how analytical method validation is approached for SIFT-MS so that data collected can be used to support regulatory requirements. This is achieved by applying a strategic approach in accordance with ICH Q2(R1) guidelines. Finally, we will illustrate SIFT-MS method validation using two case studies: 1) common toxic volatiles in water, 2) BTEX in soil following methanolic extraction.
Residual Monomer Analysis
In this paper, the unique capabilities of SIFT-MS are illustrated for residual monomer analysis, using formaldehyde emissions from polyoxymethylene (POM) polymer to illustrate. SIFT-MS provides significant throughput increases for both testing laboratories and quality assurance/quality control (QA/QC) in a process environment.
Formaldehyde: Real-time, Sensitive Gas and Headspace Analysis Using SIFT-MS
Various exciting applications of SIFT-MS formaldehyde analysis will be presented, including candle flame analysis, material emissions and evaluation of materials that scavenge gaseous formaldehyde.
Direct MS Simplifies Analysis of Challenging Compounds
This webcast focuses on case studies that demonstrate simple analysis of chromatographically challenging compounds. Formaldehyde receives special attention, as it is important across a wide range of industries (from environmental to pharmaceutical testing).
Pharma Method Validation - Formaldehyde
This application note demonstrates that by applying a strategy in accordance with International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) Validation of Analytical Procedures: Text and Methodology Q2(R1) Guidelines (or “ICH Q2(R1)”) to direct analysis methods using SIFT-MS, successful validation is readily achieved – even for formaldehyde.
Rapid, Simplified Residual Solvent and Volatile Impurity Analysis Using SIFT-MS
This webinar describes SIFT-MS applications in the pharmaceutical industry, including:
- Its use as an alternative procedure for USP <467> residual solvent analysis
- Rapid, quantitative analysis of leachable formaldehyde from polyoxymethylene polymer and PEG excipient
- High-throughput headspace screening for nitrosamine residues in drug products
- Fast turnaround, simplified analysis of ethylene oxide residues in detergents used for cleaning validation.
Rapid Volatile Impurity Analysis in Pharmaceutical Products Using SIFT-MS
SIFT-MS quantifies volatile compounds that are chromatographically challenging such as formaldehyde, formic acid and ammonia. Direct, real-time analysis using SIFT-MS provides new opportunities across multiple pharma applications, including:
- Simple formaldehyde analysis
- Packaging screening, including residual monomer analysis
- Residual solvent analysis
- Cleaning validation
- Production facility air quality monitoring
- Bioreactor monitoring
Formaldehyde in Air (sample bags)
Direct analysis using selected ion flow tube mass spectrometry (SIFT-MS) enables real-time monitoring of formaldehyde to sub-part-per-billion concentrations. SIFT-MS simplifies and accelerates both sampling and analysis of formaldehyde, providing 25-fold throughput enhancements.
SIFT-MS represents a major breakthrough for the pharmaceutical industry due to its ability to comprehensively analyze diverse VOCs and inorganic gas impurities with very high sample throughput. It quantifies VOCs directly in real-time to sub-part-per-billion (ppb) concentrations, so that product issues are detected earlier and resolved immediately, delivering economic benefits to all stakeholders.