SIFT-MS delivers high-throughput solutions that eliminate bottlenecks in development, production, and QA/QC environments.
The real-time data output of SIFT-MS significantly shortens time to data and increases sample throughput. Analytical bottlenecks in pharma and CDMO applications can be overcome, increasing capacity and operational efficiency in applications such as residual solvent analysis, nitrosamine characterization, ethylene oxide and impurity detection, and detergent and sterilization monitoring.
Pharma and CDMO applications and use cases
Small Polar Molecules
SIFT-MS simplifies detection of small polar species by analyzing them directly from gas or headspace to sub-ppbV concentrations, without requiring derivatization or preconcentration.Read More
Residual Solvent Analysis
SIFT-MS provides rapid characterization of compounds that are not easily monitored by other technologies.Read More
Drug Delivery Devices
SIFT-MS provides a very rapid and highly sensitive solution for the detection of residual monomers and other impurities in diverse drug delivery devices.Read More
SIFT-MS revolutionizes packaging testing across diverse materials with its ability to analyze a very wide range of compounds rapidly.Read More
Syft is your answer in the Pharmaceutical industry
Industry issueFor pharmaceutical companies investing in scale-up of their manufacturing processes, the associated scaling of residual solvent testing using the USP<467> procedure requires significant upscaling of analysis capacities. This involves increased investments in qualified personnel, lab space, validation procedures and maintenance as well as higher overall instrument acquisition and running costs.
Competitive benefitThe validated SIFT-MS procedure meets the acceptance criteria in USP<1467>, and with 17-fold higher sample throughput, addresses current scale-up issues for residual solvent testing in the pharmaceutical industry.
Industry impactSince SIFT-MS uses direct, chromatography-free analysis, practical issues for the front-end separation are eliminated, resulting in a robust and reliable analytical result that is easily obtained and requires less qualified personnel. Capacity increase can thus be reached with just a single automated SIFT-MS instrument.
Rapid Volatile Impurity Analysis in Pharmaceutical Products Using SIFT-MS
Rapid, Simplified Residual Solvent and Volatile Impurity Analysis Using SIFT-MS
Drying Endpoint Monitoring Using SIFT-MS For Enhanced Manufacturing Of Active Pharmaceutical Ingredients
Process analysis using SIFT-MS enables the drying process to be monitored past the drying end-point measurable using conventional weighing methods. This delivers greater efficiencies for production, and lowers risk of thermally damaging sensitive APIs.
Simple, Rapid Analysis Of Ethylene Oxide In A Polysorbate 80 Excipient Using SIFT-MS
Quantitative ethylene oxide analysis in Polysorbate 80 excipient is greatly simplified using SIFT-MS, with a time to first test result that is eight-fold faster than the current compendial method and a
daily sample throughput that is 9- to 14-fold higher.
Routine Analysis 1: Why Labs and CROs Should Adopt Direct MS
Routine Analysis 4: Direct MS Simplifies Analysis of Challenging Compounds
Syft Application Talks 5: Determination of the Supercritical Carbon Dioxide Extraction End-Point
Part 4: Biomedical and Pharma
Online Demonstration: Pharmaceutical Applications
Pharmaceutical Method Validation for SIFT-MS
Simple, Rapid Analysis Of N-Nitrosodimethylamine (NDMA) Impurity In Ranitidine Products Using SIFT-MS
Quantitative analysis of volatile nitrosamine impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods.
Simple, Rapid Analysis Of Formaldehyde Impurities In Gelucire Excipient Using SIFT-MS
SIFT-MS greatly simplifies formaldehyde detection and quantitation through direct, instantaneous, and sensitive (sub-ppbV) sample ionization, yielding sample throughputs of up to 250+ samples/day.
Rapid Residual Solvent Analysis Validation Of An Alternative Procedure For USP Method <467> Using SIFT-MS
This study demonstrates that SIFT-MS provides an alternative procedure to USP<467>. Because SIFT-MS is inherently a rapid test technique (all sample components are simultaneously analyzed in about one minute per sample), this validated procedure can be used in organizations that require high-throughput testing, providing 17-fold daily throughput increase over GC-FID.
Simple Rapid Analysis of NDMA in a Recalled Valsartan Product Using SIFT-MS
Quantitative analysis of NDMA impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods.