
Enhanced Headspace-SIFT-MS Analysis of Aqueous Solutions using Salts and Surfacants
This technical note explores how salts (e.g., K₂CO₃) enhance VOC partitioning and surfactants (e.g., SDS) improve solubility in headspace-SIFT-MS analysis. These techniques boost sensitivity and expand applications in pharmaceuticals, environment, and industry.

Leveraging Variable Sample Injection Speeds for Simplified Sensitivity Changes and Calibration
This technical note explores the benefits of leveraging variable sample injection speeds in automated SIFT-MS. Learn how adjustable injection rates enable seamless sensitivity changes, reduced environmental impact, faster calibrations, and enhanced flexibility for analyzing volatile organic compounds. Discover workflow improvements, sustainability gains, and applications in headspace analysis with high precision and efficiency.

SIFT-MS Mobile Laboratory: Pollution Source Identification
This application note showcases an innovative approach used in South Korea, where fenceline monitoring and mobile laboratories equipped with SIFT-MS enable rapid, on-site analysis of volatile pollutants. Learn how this powerful combination delivers precise, real-time data to trace emissions back to their sources with unmatched efficiency.

SIFT-MS Mobile Laboratory: Spatial Mapping of Volatile Polluntants
This application note highlights the innovative use of SIFT-MS for real-time mapping of volatile organic compounds (VOCs) in industrial complexes. Learn how mobile laboratories enable on-the-move spatial data acquisition, improving response times to pollution incidents and enhancing environmental and public health monitoring.

SIFT-MS: A Highly Reproducible Real-Time Trace Gas Analysis Technology
This whitepaper highlights the exceptional reproducibility of Syft Technologies' SIFT-MS instruments, showcasing fleet performance across legacy and latest-generation platforms. By comparing standardized analytical methods on multiple instruments, it demonstrates high consistency in trace gas quantitation with 95% confidence intervals below 21% for the Syft Tracer and 38% for legacy devices. The findings emphasize Syft's commitment to advancing reliable, real-time analysis solutions for diverse applications.

Progress with Alternative Solvents for SIFT-MS: 2024 Update
This technical note explores advancements in utilizing alternative solvents for SIFT-MS, emphasizing updates from 2024. It introduces three new solvents—acetonitrile, N,N'-dimethylpropyleneurea (DMPU), and propylene glycol (PG)—and highlights the enhanced sensitivity and applications of existing solvents like triacetin. The findings demonstrate significant benefits in analyzing diverse volatile organic compounds (VOCs) while addressing challenges in method development, such as solvent-specific carryover and partitioning behaviors.

Rapid and Quantitative Screening of Nitrosamines in Drug Products Using Headspace-SIFT-MS
This study demonstrates that headspace-SIFT-MS meets United States Pharmacopeia (USP) criteria for six nitrosamines, achieving low limits of quantitation (0.06 ppm for NDMA and 0.03 ppm for NDEA) even in complex drug matrices. With high recovery rates and significant reductions in solvent usage, consumables, and operational complexity compared to traditional chromatographic methods, the Syft Tracer Pharm11 solution is an efficient screening tool for nitrosamines and volatile impurities.

High-Throughput Headspace Analysis of Volatile Impurities in Consumer Products Using Standard Additions
This application note demonstrates the use of SIFT-MS to optimize the Method of Standard Additions (MoSA) for quantifying volatile impurities in complex matrices such as emulsions. SIFT-MS significantly reduces costs by increasing sample throughput, enabling simultaneous analysis of diverse functionalities, and supporting a wide range of analytes and matrices with a single instrument configuration. The study highlights the efficient analysis of toxic volatile impurities—benzene, 1,4-dioxane, and formaldehyde—in various consumer products and its impact on improving analytical workflows.

Rapid Quantitative Analysis of Ethylene Oxide and 1,4-Dioxane in Polymeric Excipients Using SIFT-MS
This application note highlights the use of SIFT-MS for the rapid and efficient analysis of ethylene oxide and 1,4-dioxane in pharmaceutical excipients, as outlined in USP Chapter <228>. SIFT-MS streamlines this workflow by eliminating matrix-matched preparation and reducing run times, achieving 9- to 14-fold higher throughput while maintaining high analytical sensitivity. Additionally, SIFT-MS requires 10 times less sample per analysis, making it a more efficient and cost-effective alternative to GC methods.

IFFC 2024: Application of Direct-Injection Mass Spectrometry to Rapid Aroma Screening: Food and Packaging Case Studies
Watch Dr. Vaughan Langford present "Application of Direct-Injection Mass Spectrometry to Rapid Aroma Screening: Food and Packaging Case Studies" at IFFC 2024. Learn about how SIFT-MS provides fast, reliable targeted and untargeted analysis for food and packaging samples.

Coffee Roastery Emission Testing Using SIFT-MS
This application note describes how SIFT-MS was used to simultaneously detect 26 VOCs during coffee bean roasting from three locations: the roasting room air, the exhaust stack (pre-filtration), and the exhaust exit (post-filtration). The results showed significant reductions (3-62-fold) in emissions following the wet-scrubber filtration and demonstrate SIFT-MS as a reliable solution for real-time emissions testing.
Real-Time Analysis of Ephemeral Odors from Horace, the Blooming Corpse Flower, by SIFT-MS
This app note describes how SIFT-MS was used to measure short-lived odor species given off by a blooming titan arum flower during the spring of 2024. Seven odorous VOCs were identified from full-scan data taken from within the blooming flower and compared with air surrounding the flower from three days prior to bloom. Results suggest that dimethyl disulfide is responsible for the constant mild stink that the flower gives off, while the other VOCs that were elevated only when in bloom are responsible for the rotting flesh characteristic commonly described with this type of flower.