Knowledge Base

Learn more about the power of trace gas analysis using SIFT-MS. Download our latest brochures, application notes and white papers or watch an application-focused video. Questions? Contact us!

SIFT-MS is a direct, real-time mass spectrometry (MS) technique which offers revolutionary volatile compound analysis capabilities to Pharma and CDMO labs due to its fast time to data, time efficient workflows, analytical flexibility, and ease of use. It expedites analytical workflows, such as residual solvents analysis, by generating faster results than traditional methods. Syft Tracer Pharm11 is a SIFT-MS-based solution that includes SyftAuditTracer software designed for 21 CFR Part 11 compliant environments. This app note describes how volatile impurities can be characterized in real-time including nitrosamines, ethylene oxide, and residual solvents.

This talk showcases environmental and food safety applications where SIFT-MS overcomes limitations of traditional chromatographic approaches resulting in faster time to data, significantly higher throughput, and more accurate determination of product and environmental contaminants.  Mobile and fenceline environmental use cases from the United Kingdom, New Zealand, China, and Korea are presented.

A rapid analysis method is needed to ensure food safety by high-throughput screening for ethylene oxide contamination. SIFT-MS is a suitable method for rapid quantification of trace amounts of EtO vapors in the headspace of food samples.  This study shows experimental data that reveals how the OH− reagent ion is suitable for overcoming product ion overlap and interferences observed with other reagent ions in this analysis. 

This publication reviews best practices for quantitating volatile compounds in a wide range of applications using a multicomponent gas standard.  Details of the approach to calculating concentrations from ion−molecule reaction kinetics based on reaction times and instrument calibration functions determined from known concentrations in the gas standard mix are discussed.

This publication reviews VOC pollutant monitoring applications of SIFT-MS in South Korea.  SIFT-MS has been applied to emission source characterization, fenceline monitoring, ambient monitoring, pollution mapping, and incident response (including the use of drone-based sampling) for hazardous air pollutants (HAPs), odor nuisance species, and compounds that have high ozone formation potential (OFP) and/or contribute to secondary aerosol (SOA) formation.

Watch this on-demand webinar featuring Mark Perkins (Element), Professor Chris Price (CMAC, University of Strathclyde) and Aaron Smith (CMAC, University of Strathclyde) to learn how SIFT-MS provides real-time analysis of volatile impurities when determining solvent drying end points, volatile degradation products, or volatile impurities during hot melt extrusion.

In this application note, enhanced MHE workflows are demonstrated using styrene, formaldehyde, and NDMA analyses in polystyrene polymer, Gelucire excipient, and ranitidine drug products, respectively. Reduced calibration frequency in routine analysis enables significant workflow benefits to be realized, including four-fold faster time to first result for quantitative analysis of condensed-phase samples.  Over 220 samples per day can be analyzed quantitatively for diverse volatile impurities using the enhanced MHE-SIFT-MS workflow.

Read the application note, "High Throughput SIFT-MS Quantitative Analysis of Beer Using the Method of Standard Additions," to learn how automated headspace-SIFT-MS quantitatively analyzes VOCs in beer with throughput of 12 samples / hr and time to first result that is >2X faster than chromatographic methods. 

In this webinar, we introduce our new compliant real-time mass spectrometer solution, Syft Tracer Pharm11. A single instrument is capable of running up to 220 samples per day, and multiple methods and analyses can be performed in sequence. The direct headspace-SIFT-MS instrument is chromatography-free, and therefore the need for multiple columns and instrument downtime between methods does not exist.  We will highlight several common CDMO tests that have been performed and validated using headspace SIFT-MS, including residual solvents, ethylene oxide, nitrosamines and other extractables & leachables.

Learn about the world's only 21 CFR Part 11 compliant real-time mass spec, Syft Tracer Pharm11, which is launching at Contract Pharma and debuting at AAPS 2023 PharmSci 360!

This webinar features David Light of Valisure and includes case studies that demonstrate how SIFT-MS provides faster and more accurate analysis of volatile impurities in consumer products.  Learn how benzene has been detected in commercial products like dry shampoo and sunscreens.  

This application note summarizes the SIFT-MS results obtained in a study of exposure to VOCs from 26 retail sunscreen products – both VOCs intended as ingredients and those present as contaminants. The commercial products varied widely in VOC content and hence user exposure. Several products contained benzene contamination that was readily quantified using dynamic headspace-SIFT-MS analysis.