Reagent ion generation and selection: SIFT-MS uses soft chemical ionization to generate mass-selected reagent ions that can rapidly quantify VOCs to low parts-per-trillion concentrations (by volume, pptv). Eight reagent ions (H3O+, NO+, O2+, O-, OH-, O2-, NO2- and NO3-) are obtained from a microwave discharge of moist or dry air. One reagent ion is selected at any particular time using a quadrupole mass filter.
Analyte ionization: The selected reagent ion is injected into the flow tube and excess energy is removed through collisions with the carrier gas. The sample is then introduced at a known flow rate and the reactive compounds it contains are ionized by the reagent ion to form well-characterized product ions. Rapid switching between reagent ions provides high selectivity because the multiple reaction mechanisms provide additional independent measurements of each analyte. The multiple reagent ions also help to remove uncertainty from isobaric overlaps in mixtures containing multiple analytes.
Analyte detection and quantitation: Product ions are sampled into a second quadrupole mass filter. Utilizing Syft's compound library, the software instantaneously calculates each analyte's concentration. This process enables real-time analysis of air samples at trace and ultra-trace levels without the requirement of pre-concentration.
SIFT-MS delivers real-time, chromatography-free direct analysis of compounds that traditionally require intensive sample preparation. No sample preparation is required for even complex matrices and high-humidity samples. SIFT-MS analyzes compounds that cannot be easily targeted by traditional chromatographic methods such as formaldehyde, hydrogen sulfide, ammonia, ethylene oxide, and nitrosamines.
SIFT-MS is a high-throughput solution that increases analytical capacity and speeds up time to data. Syft Technologies instrumentation unlocks bottlenecks across industries and applications by providing the broadest range of compound detection with instant results to non-technical users in a user-friendly format.
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