Knowledge Base

Learn more about the power of trace gas analysis using SIFT-MS. Download our latest brochures, application notes and white papers or watch an application-focused video. Questions? Contact us!

SIFT-MS greatly simplifies formaldehyde detection and quantitation through direct, instantaneous, and sensitive (sub-ppbV) sample ionization, yielding sample throughputs of up to 250+ samples/day.

Quantitative analysis of volatile nitrosamine impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods.

Combining the power of direct analysis using selected ion flow tube mass spectrometry (SIFTMS) and GERSTEL automation, headspace analysis of chlorinated volatile organic compounds (VOCs) in water is greatly simplified. This application note demonstrates the linearity and and repeatability achievable with automated SIFT-MS. The sample throughput achievable with SIFTMS is at least three-fold higher than traditional purge-and-trap gas chromatography methods.

Direct mass spectrometry (DMS) techniques struggle to speciate ethylbenzene from the xylene isomers, yet increasingly regulators are imposing different emission and exposure limits for these compounds. This application note describes a significant breakthrough for DMS, because selected ion flow tube mass spectrometry (SIFT-MS) readily achieves direct, real-time speciation of the xylenes from ethylbenzene.

Watch this webinar to learn about some of the key benefits of simple, direct analysis for your samples.  See why direct mass spectrometry is preferred by Dr. Sheryl Barringer of The Ohio State University.  See examples of how SIFT-MS out paces chromatographic methods in both analysis speed and throughput. 

Mark describes how the ICH Q 2 (R1) guidelines can be readily applied to SIFT-MS methods, whether in scenarios where only the analytical technique is changed or for tasks that pose a unique analytical challenge. He presents case studies for two such scenarios: 1) methanolic extraction of BTEX compounds (benzene, toluene, ethylbenzene plus xylenes) from soil, 2) direct analysis of formaldehyde leaching into single-use pharmaceutical devices from polymeric components.

In this first episode, Dr Perkins answers the important question:

Why Automate Analysis?

This webinar introduces the benefits of automation and discusses how they can be applied to SIFT-MS, enabling straightforward adoption by the contract laboratory.

In this second episode, Dr Perkins provides a practical guide to automated static headspace (SH) analysis with SIFT-MS.  You will learn how SH-SIFT-MS can address throughput challenges and simplify analysis of chromatographically challenging species.

In this third episode, Dr Perkins describes the application of SIFT-MS to multiple headspace extraction (MHE).  You will learn how to determine matrix-independent concentrations from MHE. Furthermore, Dr Perkins describes how the speed of SIFT-MS analysis can be leveraged to accelerate method development for both SIFT-MS and conventional methods – for example, through rapid determination of headspace equilibration times.

In this fourth episode, Dr Perkins describes how simply and rapidly traditional instrument calibration is achieved with the automated SIFT-MS configuration. Traditional calibration approaches have not featured regularly in the SIFT-MS literature due to the widespread use of reliable library-based quantitation. However, calibration is essential for contract testing laboratories, so it is addressed in detail and from a number of different angles in this webinar.

In this fifth episode, Dr Perkins describes the novel continuous headspace analysis (CHA) technique that he developed to measure stripping of volatiles. (Note: CHA is not to be confused with dynamic headspace analysis!).  In addition, Mark describes simple, very high-throughput gas sample bag analysis and touches on other recent developments – including thermal desorption-SIFT-MS.

In this sixth and final episode, Dr Perkins reflects on the automation journey and shares his practical "hot tips" for a wide variety of automated analyses.  The webinar (and series!) concludes with a discussion of how automated SIFT-MS is an excellent complementary technique to the conventional laboratory "workhorse" techniques: gas and liquid chromatography.