The pharmaceutical industry has traditionally favored batch manufacturing driven by process complexity and relatively small scale of operation compared to the rest of the chemical sector. However, the industry is facing significant change as demands from patients, payers, and healthcare systems drive increased complexity in the design, development, manufacturing, and supply of future medicines. One way this is being addressed is through a shift to continuous manufacturing to increase consistency, reduce operating costs, and implement advanced process control based on real-time measurements.
Selected ion flow tube mass spectrometry (SIFT-MS) is a direct-injection mass spectrometry technique that addresses the needs of continuous manufacturing through real-time, broad-spectrum, high-sensitivity analysis that can be validated according to conventional pharmaceutical industry guidelines. This webinar demonstrates application of real-time SIFT-MS analysis to:
- Determine solvent-drying endpoints in state-of-the-art active pharmaceutical ingredient (API) drying systems.
- Enhance speciation and quantitation of volatile degradation products—including acetic acid, acetic anhydride, and butenal—during thermogravimetric analysis (TGA).
- Identify and quantitate trace volatile impurities during hot-melt extrusion of oral dose formulations.
Join to learn how SIFT-MS is simply faster.
Key Learning Objectives:
- Understand the fundamental features of SIFT-MS compared to conventional GC-MS, including its ability to analyze samples in real time with high specificity.
- Through case studies, understand how readily SIFT-MS instrumentation is integrated with continuous manufacturing equipment.
- Learn how SIFT-MS provides immediate feedback on trace volatile compounds in pharmaceutical products from residual solvents to impurities formed in-process through thermal degradation.
Who Should Attend:
- QA/QC managers, scientists, and engineers
- R&D engineers and scientists
- Laboratory managers/directors/supervisors
- Analytical chemists
- Production scientists and engineers
- API manufacturers
- Formulation specialists
- Excipient manufacturers
- Consumer safety scientists