Closed System Transfer Devices – Performance Testing Using SIFT-MS
Dr Mark Perkins, Senior Applications Chemist, Anatune Limited, United Kingdom
Leakage from closed system transfer devices (CSTDs) can pose significant health and safety risks to medical professionals administering pharmaceuticals such as anti-cancer drugs. Measurement of leaks using FTIR and TD-GC/MS have limitations in terms of sensitivity and time resolution, respectively. Dr Mark Perkins (Anatune Limited, UK) and Alan Wilkinson (Biopharma Stability Testing Laboratory, UK) collaborated to evaluate SIFT-MS for determination of CSTDs using protocols previously developed by NIOSH (USA). Using propylene glycol methyl ether (PGME) as a surrogate, SIFT-MS detects sub-microlitre volume leaks from these devices.
Join this Syft Application Talk presented by Mark Perkins to learn more!
Dr Mark Perkins is a senior applications chemist and SIFT-MS expert at Anatune Limited, based in Cambridge, United Kingdom. Mark joined Anatune in early 2015. His current role supports and expands the analytical capability of SIFT-MS – with a particular focus on autosampler integration and the development of automated test methods. Prior to joining Anatune, Mark graduated from the University of Southampton, UK, with a Ph.D. in electrochemistry. Then he joined the Malaysian Rubber Board’s UK research center as a senior analyst, running the gas and liquid chromatography section – eventually becoming the head of the whole analytical section.