Syft Technologies

SIFT-MS overview

What makes us different

Selected ion flow tube mass spectrometry (SIFT-MS) is a form of direct mass spectrometry that analyses volatile organic compounds (VOCs) and permanent gases in air, with typical detection limits at parts-per-trillion levels (by volume: pptV). Real-time, quantitative analysis is achieved by applying precisely controlled ultra-soft chemical ionization (USCI), coupled with mass spectrometric detection. With direct SIFT-MS, the need for sample preparation, pre-concentration and chromatography is eliminated.

Other key benefits of SIFT-MS include:

    • Instantaneous, quantitative analysis of air and headspace with very high sensitivity and selectivity
    • Direct analysis of high humidity samples
    • Simultaneous analysis of chemically diverse VOCs (e.g. aldehydes, amines and organosulfurs)
    • Simplicity of operation
    • Low maintenance and long-term stability

SIFT-MS is an ideal tool for high-throughput and real-time gas analysis applications. Syft’s SIFT-MS instrumentation is industry proven, providing non-technical operators with laboratory-grade chemical analysis, presented in an easily understandable and user-friendly format.

Imperial College

Syft Technologies is proud to be collaborating with Professor George Hanna, PhD, FRCS, Head of Department of Surgery and Cancer at Imperial College London. Professor Hanna’s world-leading research is focused on delivering better outcomes for those with gastro-intestinal cancers, through earlier breath-based diagnosis using SIFT-MS.

George Hanna
Professor at Imperial College London

Three fundamental components of SIFT-MS

1. Reagent ion generation and selection.The eight SIFT-MS reagent ions are formed by microwave discharge through moist or dry air at low pressure. One reagent ion is selected at any particular time using the second quadrupole mass filter.

2. Analyte ionization. The selected reagent ion is injected into the flow tube and excess energy is removed through collisions with the carrier gas. The sample is then introduced at a known flow rate and the reactive compounds it contains are ionized by the reagent ion to form well-characterized product ions.

3. Analyte detection and quantitation. Product ions and unreacted reagent ions are sampled into a second quadrupole mass spectrometer. Utilizing Syft’s compound library, the software instantaneously calculates each analyte’s absolute concentration.

How does SIFT-MS work?

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