Conventional residual solvents analysis is offline, so it’s costly to have APIs, excipients or finished product fail. Typically product will be over-dried for safety’s sake, but this costs more time and reduces drier throughput, plus it can harm products.

Direct analysis of drier effluent gas using SIFT-MS can enable precise drying endpoints to be achieved due to a unique combination of high sensitivity, high specificity, and broad-spectrum solvent analysis – in real time. For high-value APIs, SIFT-MS is a “must”!

And remember, with SIFT-MS you can analyze toxic impurities, such as volatile nitrosamines, formaldehyde, ethylene oxide, and benzene in the online analysis.

Read more about online solvent drying in this new app note.