Drying Endpoint Monitoring Using SIFT-MS for Enhanced Manufacturing of Active Pharmaceutical Ingredients

54 days ago

Conventional residual solvents analysis is offline, so it’s costly to have APIs, excipients or finished product fail. Typically product will be over-dried for safety’s sake, but this costs more time and reduces drier throughput, plus it can harm products.

Direct analysis of drier effluent gas using SIFT-MS can enable precise drying endpoints to be achieved due to a unique combination of high sensitivity, high specificity, and broad-spectrum solvent analysis – in real time. For high-value APIs, SIFT-MS is a “must”!

And remember, with SIFT-MS you can analyze toxic impurities, such as volatile nitrosamines, formaldehyde, ethylene oxide, and benzene in the online analysis.

Read more about online solvent drying in this new app note.