Knowledge Base
Learn more about the power of trace gas analysis using SIFT-MS. Download our latest brochures, application notes and white papers or watch an application-focused video. Questions? Contact us!
What's in Your Air? Protecting the Environment and People with SIFT-MS
In this presentation from Analytica 2024, Marino Beenhakker and Dr. David Muller describe environmental and consumer product applications of next-gen SIFT-MS including ambient air monitoring in New Zealand and PFAS measurement in consumer goods.
High-Throughput Quantitation of NDMA in Recalled Metformin using Headspace-SIFT-MS
This application note describes a headspace-SIFT-MS method for the analysis of N-nitrosodimethylamine (NDMA) that compares well with LC-MS/MS approaches and holds a 3X throughput advantage. Seamless transitions between test methods make Syft Tracer the most efficient and flexible instrument for analysis of volatile impurities, including in QC applications.
Rapid Screening and Quantitation of Hazardous Volatile Impurities in Personal Care Products by Headspace-SIFT-MS
This publication describes the suitability of headspace-SIFT-MS as a potential all-in-one approach to the combined analysis of benzene, 1,4-dioxane, and formaldehyde in personal care products (PCPs). The results suggest that the headspace SIFT-MS method may hold an 8- to 30-fold throughput advantage over conventional GC-MS analyses.
Quantitative Analysis of NDMA in Drug Products
This paper describes a proposed high-throughput method for analyzing nitrosamines in drug product using Headspace–SIFT-MS. In this study, N-nitrosodimethylamine (NDMA) was quantified directly and rapidly from drug product without dissolution, at levels well below the regulatory acceptable intake of 96 ng day−1. Use of the novel MHE-SIFT-MS approach may enable a wider screening of drug products to be conducted, since it provides around a three-fold increase in daily sample throughput.
Real-Time Analysis of Volatile PFAS Compounds in Ambient Air
This presentation from Dr. Leslie Silva at Pittcon 2024 describes preliminary work that demonstrates the ability of SIFT-MS to analyze volatile PFAS compounds in real-time. The use of negative reagent ions gives SIFT-MS a distinct selectivity advantage over competing technologies and legacy chromatographic methods.
Supporting 21 CFR Part 11 Regulated Workflows with Next Gen SIFT-MS
This white paper describes how SyftAuditTracer software supports compliance with 21 CFR Part 11 regulations in pharma and CDMO environments. SyftAuditTracer is part of the Syft Tracer Pharm11 bundle solution for high-throughput, compliant workflows.
Syft Contributes Real-Time VOC Data to Aeroparts VOC Ozone Converter Bleed Air Study
This video describes the bleed air study led by AeroParts in Oct 2023 to understand the differences in VOC ozone converter performance. VOC ozone converters have the potential for preventing airplane cabin smoke odor fume events. Learn how SIFT-MS enabled this important study by providing real-time VOC analysis of simulated engine bleed air.
Accelerating residual solvents analysis in 21 CFR Part 11 compliant settings through real-time mass spectrometry
SIFT-MS is a direct, real-time mass spectrometry (MS) technique which offers revolutionary volatile compound analysis capabilities to Pharma and CDMO labs due to its fast time to data, time efficient workflows, analytical flexibility, and ease of use. It expedites analytical workflows, such as residual solvents analysis, by generating faster results than traditional methods. Syft Tracer Pharm11 is a SIFT-MS-based solution that includes SyftAuditTracer software designed for 21 CFR Part 11 compliant environments. This app note describes how volatile impurities can be characterized in real-time including nitrosamines, ethylene oxide, and residual solvents.
Next-Generation Workflows for Environmental Monitoring and Food Safety using SIFT-MS
This talk showcases environmental and food safety applications where SIFT-MS overcomes limitations of traditional chromatographic approaches resulting in faster time to data, significantly higher throughput, and more accurate determination of product and environmental contaminants. Mobile and fenceline environmental use cases from the United Kingdom, New Zealand, China, and Korea are presented.
Quantification of Ethylene Oxide Contamination in the Presence of Acetaldehyde
A rapid analysis method is needed to ensure food safety by high-throughput screening for ethylene oxide contamination. SIFT-MS is a suitable method for rapid quantification of trace amounts of EtO vapors in the headspace of food samples. This study shows experimental data that reveals how the OH− reagent ion is suitable for overcoming product ion overlap and interferences observed with other reagent ions in this analysis.
Volatile Compounds Quantitative Analysis Using Automated SIFT-MS with Multicomponent Gas Standard
This publication reviews best practices for quantitating volatile compounds in a wide range of applications using a multicomponent gas standard. Details of the approach to calculating concentrations from ion−molecule reaction kinetics based on reaction times and instrument calibration functions determined from known concentrations in the gas standard mix are discussed.