Knowledge Base

Learn more about the power of trace gas analysis using SIFT-MS. Download our latest brochures, application notes and white papers or watch an application-focused video. Questions? Contact us!

Application Note

Extending SIFT-MS Residual Solvent and Volatile Impurity Analysis to Water-Insoluble Articles

SIFT-MS can analyze residual solvents and other volatile impurities in water-insoluble articles using a two-step process: dissolution in compatible solvent, then dilution in water. This application note describes a systematic evaluation of the compatibility of six organic solvents with headspace-SIFT-MS analysis following this two-step process.  Quantitative headspace analysis is achieved at 12 samples/hr, providing significant productivity improvements compared with chromatographic approaches.

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Application Note

Headspace-SIFT-MS: Flexibility that Revolutionizes Workflows for Diverse Samples

The characteristic flexibility, stability, high throughput, and fast time to data of the Syft Tracer next-gen SIFT-MS instrument apply across multiple headspace approaches for diverse matrices. This application note briefly summarizes the use of (1) dissolution, (2) multiple headspace extraction (MHE), and (3) the method of standard additions, then provides a guide for identifying the appropriate headspace approach for various matrices.

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Application Note

Wastewater Odor Analysis by SIFT-MS

In this application note, the performance of SIFT-MS is evaluated for analysis of odors from diverse sources at a modern wastewater treatment plant (WWTP). SIFT-MS provides comprehensive, quantitative profiling of odor sources and can identify operational abnormalities.  In particular, the results presented demonstrate that methyl mercaptan is almost always a more significant odorant at this WWTP than hydrogen sulfide and confirm that the relative abundances of these odorants vary significantly.

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Application Note

Application Brief: Revolutionary Workflows for Volatile Impurities Analysis

This application brief summarizes a scenario relevant to contract research organization (CRO) and contract drug manufacturing organization (CDMO) laboratories where multiple volatile impurity methods need to be conducted in short runs. Five analyses are considered that can be handled by one Syft Tracer but require multiple legacy, chromatography instruments. For these analyses, SIFT-MS reports the first quantitative results 2- to 12-fold faster, and has sample throughputs 3- to 17-fold higher than the conventional procedures.

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Application Note

High Throughput SIFT-MS Analysis of Formaldehyde in Fragrances Using the Method of Standard Additions

This application note describes high throughput analysis of formaldehyde in fragrances that utilizes a method of standard additions to overcome matrix effects from variable headspace compositions of the samples tested.  SIFT-MS delivers >2X faster time to data with up to 5X greater throughput than chromatographic methods. 

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Application Note

High-Throughput Analysis of Volatile Compounds in Air, Water, and Soil Using SIFT-MS

This study demonstrates high-throughput analysis of BTEX compounds from several matrices (air, water and soil). Detection limits in the single-digit part-per-billion concentration range (by volume) are readily achievable within seconds using SIFT-MS, because sample analysis is achieved without chromatography, pre-concentration, or drying.  We also present a calibration approach that enables speciation of ethylbenzene from the xylenes in real time.

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Application Note

Revolutionary Productivity For Volatile Residue and Impurity Analysis

This application note describes a scenario in which Syft TracerTM replaces five chromatography systems and still has significant available sample capacity. SIFT-MS provides rapid, chromatography-free analysis that revolutionizes multiple workflows.

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Application Note

Even Faster Quantitation Of Formaldehyde In Gelucire Excipient

This application note describes how the efficiency of a MHE workflow can be significantly improved for MHE-SIFT-MS due to the stability of the technique. Formaldehyde impurity is analyzed easily and quantitatively in Gelucire excipient with this improved approach.  The time-to-result is reduced to 85 minutes for this system – six-fold faster than the conventional MHE-SIFT-MS approach.  Quantitative analysis is achieved at the throughput of 220 samples/day.

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Brochure

Syft Tracer Brochure

Syft TracerTM is the latest advancement in real-time, direct injection mass spectrometry (MS) built to solve the most difficult analytical challenges faced within a variety of industries and applications.  This advancement to SIFT-MS delivers trace-level detection sensitivity, unparalleled performance stability, superior selectivity, and highly reproducible, quantitative data.  Syft Tracer is optimized for high-throughput environments where continuous operation is the standard.  Never miss a product or environmental contamination event again.

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Webinar

The Latest Innovation of Real-Time, High-Throughput Volatile Impurities Analysis by SIFT-MS

Join us for this webinar to learn about Syft Tracer, the latest advancement of real-time, trace gas analysis by SIFT-MS which launched at Pittcon 2023. Hear how the recent product innovations unlock analytical bottlenecks and enable faster decisions to be made in critical process steps.

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Document

SIFT-MS: Quantifying the Volatiles You Smell . . . and the Toxics You Don’t

SIFT-MS has been widely applied to quantitative analysis of a broad range of VOCs in applications from food products to workplace safety to environmental monitoring, and most recently to pharmaceutical testing. This review surveys the applications of SIFT-MS in odor analysis and in workplace, environmental and consumer protection, with a particular focus on the complementarity of this real-time mass spectrometry analyzer to sensor technology and conventional laboratory techniques—in particular, gas chromatography–mass spectrometry (GC/MS).

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Document

Recent developments and applications of selected ion flow tube mass spectrometry (SIFT‐MS)

SIFT‐MS is now recognized as the most versatile analytical technique for the identification and quantification of trace gases down to the parts‐per‐trillion by volume, pptv, range. This statement is supported by the wide reach of its applications, from real‐time analysis, obviating sample collection of very humid exhaled breath, to its adoption in industrial scenarios for air quality monitoring. This review touches on the recent extensions to the underpinning ion chemistry kinetics library and the alternative challenge of using nitrogen carrier gas instead of helium. 

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