Knowledge Base

Learn more about the power of trace gas analysis using SIFT-MS. Download our latest brochures, application notes and white papers or watch an application-focused video. Questions? Contact us!

This webcast focuses on case studies that demonstrate simple analysis of chromatographically challenging compounds. Formaldehyde receives special attention, as it is important across a wide range of industries (from environmental to pharmaceutical testing).

This application note demonstrates that by applying a strategy in accordance with International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) Validation of Analytical Procedures: Text and Methodology Q2(R1) Guidelines (or “ICH Q2(R1)”) to direct analysis methods using SIFT-MS, successful validation is readily achieved – even for formaldehyde.

This application note describes how challenging formaldehyde residue analysis becomes routine by utilizing automated thermal desorption-selected ion flow tube mass spectrometry (TD-SIFT-MS).

This application note describes the application of MHE-SIFT-MS to detection of C1 -C10 aldehydes and other oxygenated volatile organic compounds (VOCs) in paperboard.

This webinar describes SIFT-MS applications in the pharmaceutical industry, including:

• Its use as an alternative procedure for USP <467> residual solvent analysis
• Rapid, quantitative analysis of leachable formaldehyde from polyoxymethylene polymer and PEG excipient
• High-throughput headspace screening for nitrosamine residues in drug products
• Fast turnaround, simplified analysis of ethylene oxide residues in detergents used for cleaning validation.

SIFT-MS quantifies volatile compounds that are chromatographically challenging such as formaldehyde, formic acid and ammonia.  Direct, real-time analysis using SIFT-MS provides new opportunities across multiple pharma applications, including:

• Simple formaldehyde analysis
• Packaging screening, including residual monomer analysis
• Residual solvent analysis
• Cleaning validation
• Production facility air quality monitoring
• Bioreactor monitoring

Direct analysis using selected ion flow tube mass spectrometry (SIFT-MS) enables real-time monitoring of formaldehyde to sub-part-per-billion concentrations. SIFT-MS simplifies and accelerates both sampling and analysis of formaldehyde, providing 25-fold throughput enhancements.

SIFT-MS represents a major breakthrough for the pharmaceutical industry due to its ability to comprehensively analyze diverse VOCs and inorganic gas impurities with very high sample throughput.  It quantifies VOCs directly in real-time to sub-part-per-billion (ppb) concentrations, so that product issues are detected earlier and resolved immediately, delivering economic benefits to all stakeholders.

This webinar describes continuous environmental monitoring applications and presents a variety of case studies, including:

• Fenceline monitoring
• Real-time stack gas analysis
• Odor characterization at the source
• Continuous odor monitoring

SIFT-MS provides rapid and comprehensive analysis of landfill gas, making it ideally suited to the complete range of environmental and industrial applications.

This webinar discusses chemical and sensory-like analysis of wastewater treatment by SIFT-MS.  After introducing sensory and instrumental analysis of odor, it covers a wastewater treatment plant (WWTP) case study in detail, critiquing both instrumental and sensory methods available to this market.

Syft offers a robust, field-deployable solution utilizing state-of-the-art SIFT-MS technology.  Multiple, rapidly switching reagent ions provide high selectivity, allowing for targeting of specific targets such as the epoxide ring of ethylene oxide or the aldehyde group of acetaldehyde.