Knowledge Base

Learn more about the power of trace gas analysis using SIFT-MS. Download our latest brochures, application notes and white papers or watch an application-focused video. Questions? Contact us!

Application Note

Paperboard Volatiles 1 - Screening

This application note describes the application of SH-SIFT-MS to the detection of very diverse volatiles in eleven paperboard samples with analysis times of less than one minute per sample.

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Webinar

Analysis of Volatile Emissions from Polymers and Paperboard

This webinar describes a recent addition to the portfolio of techniques available for routine sample analysis: SIFT-MS. SIFT-MS enables rapid, quantitative analysis of VOCs across the full spectrum of packaging materials.  Detailed case studies will describe applications in polymeric and paperboard emissions analysis.

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Webinar

Routine Analysis 3: SIFT-MS Method Development and Validation

In this webinar, we discuss how analytical method validation is approached for SIFT-MS so that data collected can be used to support regulatory requirements. This is achieved by applying a strategic approach in accordance with ICH Q2(R1) guidelines. Finally, we will illustrate SIFT-MS method validation using two case studies: 1) common toxic volatiles in water, 2) BTEX in soil following methanolic extraction.

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Application Note

Residual Monomer Analysis

In this paper, the unique capabilities of SIFT-MS are illustrated for residual monomer analysis, using formaldehyde emissions from polyoxymethylene (POM) polymer to illustrate.  SIFT-MS provides significant throughput increases for both testing laboratories and quality assurance/quality control (QA/QC) in a process environment. 

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Webinar

Formaldehyde: Real-time, Sensitive Gas and Headspace Analysis Using SIFT-MS

Various exciting applications of SIFT-MS formaldehyde analysis will be presented, including candle flame analysis, material emissions and evaluation of materials that scavenge gaseous formaldehyde.

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Webinar

Direct MS Simplifies Analysis of Challenging Compounds

This webcast focuses on case studies that demonstrate simple analysis of chromatographically challenging compounds. Formaldehyde receives special attention, as it is important across a wide range of industries (from environmental to pharmaceutical testing).

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Application Note

Pharma Method Validation - Formaldehyde

This application note demonstrates that by applying a strategy in accordance with International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) Validation of Analytical Procedures: Text and Methodology Q2(R1) Guidelines (or β€œICH Q2(R1)”) to direct analysis methods using SIFT-MS, successful validation is readily achieved – even for formaldehyde.

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Application Note

Formaldehyde Thermal Extraction with TD-SIFT-MS

This application note describes how challenging formaldehyde residue analysis becomes routine by utilizing automated thermal desorption-selected ion flow tube mass spectrometry (TD-SIFT-MS).

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Application Note

Paperboard Volatiles 2 - MHE

This application note describes the application of MHE-SIFT-MS to detection of C1 -C10 aldehydes and other oxygenated volatile organic compounds (VOCs) in paperboard.

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Webinar

Rapid, Simplified Residual Solvent and Volatile Impurity Analysis Using SIFT-MS

This webinar describes SIFT-MS applications in the pharmaceutical industry, including:

  • Its use as an alternative procedure for USP <467> residual solvent analysis
  • Rapid, quantitative analysis of leachable formaldehyde from polyoxymethylene polymer and PEG excipient
  • High-throughput headspace screening for nitrosamine residues in drug products
  • Fast turnaround, simplified analysis of ethylene oxide residues in detergents used for cleaning validation.
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Webinar

Rapid Volatile Impurity Analysis in Pharmaceutical Products Using SIFT-MS

SIFT-MS quantifies volatile compounds that are chromatographically challenging such as formaldehyde, formic acid and ammonia.  Direct, real-time analysis using SIFT-MS provides new opportunities across multiple pharma applications, including:

  • Simple formaldehyde analysis
  • Packaging screening, including residual monomer analysis
  • Residual solvent analysis
  • Cleaning validation
  • Production facility air quality monitoring
  • Bioreactor monitoring
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Whitepaper

Formaldehyde in Air (sample bags)

Direct analysis using selected ion flow tube mass spectrometry (SIFT-MS) enables real-time monitoring of formaldehyde to sub-part-per-billion concentrations. SIFT-MS simplifies and accelerates both sampling and analysis of formaldehyde, providing 25-fold throughput enhancements.

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