Simple analysis of Small Polar molecules
Analysis of polar and reactive species – such as formaldehyde, acetaldehyde and formic acid – is slow and complicated when using conventional chromatographic methods. SIFT-MS simplifies detection of small polar species by analyzing them directly from gas or headspace to sub-ppbV concentrations, without requiring derivatization or preconcentration.
Applications of SIFT-MS for analysis of challenging compounds include:
- Residual monomers and byproducts
- Residual solvents in pharmaceuticals
- Packaging impurities
Linear detection of formaldehyde in the ppbV range.
Small Polar Molecules benefits
Comprehensive analysis, including inorganics and chromatographically challenging compounds
Flexible sample delivery options, including automation and area sampling
Intuitive software and fast method development
High sensitivity and wide linearity range
Automated high-throughput headspace analysis
Small Polar Molecules resources
Rapid, Simplified Residual Solvent and Volatile Impurity Analysis Using SIFT-MS
Direct MS Simplifies Analysis of Challenging Componds
Routine Analysis 4: Direct MS Simplifies Analysis of Challenging Compounds
Formaldehyde: Real-time, Sensitive Gas and Headspace Analysis Using SIFT-MS
Drying Endpoint Monitoring Using SIFT-MS For Enhanced Manufacturing Of Active Pharmaceutical Ingredients
Process analysis using SIFT-MS enables the drying process to be monitored past the drying end-point measurable using conventional weighing methods. This delivers greater efficiencies for production, and lowers risk of thermally damaging sensitive APIs.
Simple, Rapid Analysis Of Ethylene Oxide In A Polysorbate 80 Excipient Using SIFT-MS
Quantitative ethylene oxide analysis in Polysorbate 80 excipient is greatly simplified using SIFT-MS, with a time to first test result that is eight-fold faster than the current compendial method and a
daily sample throughput that is 9- to 14-fold higher.
Simple, Rapid Analysis Of Formaldehyde Impurities In Gelucire Excipient Using SIFT-MS
SIFT-MS greatly simplifies formaldehyde detection and quantitation through direct, instantaneous, and sensitive (sub-ppbV) sample ionization, yielding sample throughputs of up to 250+ samples/day.
Simple Rapid Analysis of NDMA in a Recalled Valsartan Product Using SIFT-MS
Quantitative analysis of NDMA impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods.