Pharmaceutical Small Polar Molecules

Comprehensive analysis, including inorganics and chromatographically challenging compounds.

Simple analysis of Small Polar molecules

Analysis of polar and reactive species – such as formaldehyde, acetaldehyde and formic acid – is slow and complicated when using conventional chromatographic methods. SIFT-MS simplifies detection of small polar species by analyzing them directly from gas or headspace to sub-ppbV concentrations, without requiring derivatization or preconcentration.

Applications of SIFT-MS for analysis of challenging compounds include:

  • Residual monomers and byproducts
  • Residual solvents in pharmaceuticals
  • Packaging impurities

Linear detection of formaldehyde in the ppbV range.

Small Polar Molecules benefits

Comprehensive analysis, including inorganics and chromatographically challenging compounds

Flexible sample delivery options, including automation and area sampling

Intuitive software and fast method development

High sensitivity and wide linearity range

Automated high-throughput headspace analysis

Sample customers


Small Polar Molecules resources

Brochure

Pharmaceutical Applications

Pharmaceutical Industry Applications Of Sift-Ms

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Whitepaper

Formaldehyde in Air (sample bags)

High-Throughput Formaldehyde Analysis in Air Using Direct Mass Spectrometry

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Webinar

Rapid, Simplified Residual Solvent and Volatile Impurity Analysis Using SIFT-MS

Volatile impurities occur frequently in pharmaceutical products and packaging and are often of significant concern due to their toxicity.
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Application Note

Paperboard Volatiles 2 - MHE

Rapid Determination of Volatile Compound Content using Multiple Headspace Extraction-SIFT-MS

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Application Note

Formaldehyde Thermal Extraction with TD-SIFT-MS

Time-Resolved Thermal Extraction of Residual Formaldehyde Using Thermal Desorption-SIFT-MS

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Application Note

Pharma Method Validation - Formaldehyde

Validation of a High-Throughput SIFT-MS Method for Analysis of Formaldehyde Leachate

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Webinar

Direct MS Simplifies Analysis of Challenging Componds

Routine Analysis 4: Direct MS Simplifies Analysis of Challenging Compounds

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Webinar

Formaldehyde: Real-time, Sensitive Gas and Headspace Analysis Using SIFT-MS

Concerns about the toxicity of formaldehyde and its ubiquity continue to increase.
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Application Note

Drying Endpoint Monitoring Using SIFT-MS For Enhanced Manufacturing Of Active Pharmaceutical Ingredients

Process analysis using SIFT-MS enables the drying process to be monitored past the drying end-point measurable using conventional weighing methods. This delivers greater efficiencies for production, and lowers risk of thermally damaging sensitive APIs.

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Application Note

Simple, Rapid Analysis Of Ethylene Oxide In A Polysorbate 80 Excipient Using SIFT-MS

Quantitative ethylene oxide analysis in Polysorbate 80 excipient is greatly simplified using SIFT-MS, with a time to first test result that is eight-fold faster than the current compendial method and a
daily sample throughput that is 9- to 14-fold higher.

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Application Note

Simple, Rapid Analysis Of Formaldehyde Impurities In Gelucire Excipient Using SIFT-MS

SIFT-MS greatly simplifies formaldehyde detection and quantitation through direct, instantaneous, and sensitive (sub-ppbV) sample ionization, yielding sample throughputs of up to 250+ samples/day.

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Application Note

Simple Rapid Analysis of NDMA in a Recalled Valsartan Product Using SIFT-MS

Quantitative analysis of NDMA impurities in drug products is greatly simplified using SIFT-MS and has a three-fold throughput advantage (excluding sample prep benefits) over chromatographic methods.

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