Pharmaceutical Drug Delivery Devices

Syft supports product quality assurance by quantifying VOCs and SVOCs in real-time so that issues can be dealt with immediately.

Volatile residue analysis in Drug Delivery Devices

SIFT-MS provides a very rapid and highly sensitive solution for the detection of residual monomers and other impurities in diverse drug delivery devices, including orally inhaled and nasal drug products (OINDPs), and parenteral and ophthalmic drug products (PODPs).

  • Very high throughput screening via the elimination of chromatographic separation, delivering greatly reduced cost of analysis
  • High selectivity and comprehensive analysis provided by eight rapidly switchable reagent ions
  • High sensitivity, providing rapid warning of quality issues
  • Wide linear and dynamic ranges enable one instrument to be applied readily to multiple analytical tasks

Analysis of multiple residual monomers in different polymer products.

Drug Delivery Devices benefits

Comprehensive analysis, including inorganics and chromatographically challenging compounds

Flexible sample delivery options, including automation and area sampling

Intuitive software and fast method development

High sensitivity and wide linearity range

Automated high-throughput headspace analysis

Drug Delivery Devices resources

Brochure

Pharmaceutical Applications

Pharmaceutical Industry Applications Of Sift-Ms

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Whitepaper

Formaldehyde in Air (sample bags)

High-Throughput Formaldehyde Analysis in Air Using Direct Mass Spectrometry

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Webinar

Rapid, Simplified Residual Solvent and Volatile Impurity Analysis Using SIFT-MS

Volatile impurities occur frequently in pharmaceutical products and packaging and are often of significant concern due to their toxicity.
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Application Note

Formaldehyde Thermal Extraction with TD-SIFT-MS

Time-Resolved Thermal Extraction of Residual Formaldehyde Using Thermal Desorption-SIFT-MS

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Application Note

Pharma Method Validation - Formaldehyde

Validation of a High-Throughput SIFT-MS Method for Analysis of Formaldehyde Leachate

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Application Note

Residual Monomer Analysis

High-Throughput Residual Monomer
Analysis, Using SIFT-MS

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Webinar

Routine Analysis 3: SIFT-MS Method Development and Validation

SIFT-MS Method Validation

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Webinar

Analysis of Volatile Emissions from Polymers and Paperboard

Food and pharmaceutical products are susceptible to contamination from packaging – whether from polymeric materials, printing inks or paperboard.
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Application Note

Drying Endpoint Monitoring Using SIFT-MS For Enhanced Manufacturing Of Active Pharmaceutical Ingredients

Process analysis using SIFT-MS enables the drying process to be monitored past the drying end-point measurable using conventional weighing methods. This delivers greater efficiencies for production, and lowers risk of thermally damaging sensitive APIs.

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Application Note

Simple, Rapid Analysis Of Ethylene Oxide In A Polysorbate 80 Excipient Using SIFT-MS

Quantitative ethylene oxide analysis in Polysorbate 80 excipient is greatly simplified using SIFT-MS, with a time to first test result that is eight-fold faster than the current compendial method and a
daily sample throughput that is 9- to 14-fold higher.

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Application Note

Simple, Rapid Analysis Of Formaldehyde Impurities In Gelucire Excipient Using SIFT-MS

SIFT-MS greatly simplifies formaldehyde detection and quantitation through direct, instantaneous, and sensitive (sub-ppbV) sample ionization, yielding sample throughputs of up to 250+ samples/day.

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