Sensitive, high-throughput detection of personal care product contaminants
SIFT-MS offers faster, more sensitive detection of contaminants in commercial personal care products than traditional methods. Matrix effects due to the complex and variable compositions of the personal care products are effectively addressed through utilization of standard additions in a matrix-matching approach. The high sample throughput of SIFT-MS means that calibration curves for each matrix are generated rapidly compared to gas chromatography-based analyses, making the standard additions approach far more economic when using SIFT-MS with faster time to first result. SIFT-MS has also been shown to detect carcinogens like benzene with 10-50X greater sensitivity than GC methods because of its ability to directly sample the products.
Real-time and high-throughput analysis option
High sensitivity and wide linearity range
Designed and engineered for demanding laboratory, R&D, and process-line applications
Automated headspace analysis
Intuitive software and flexible testing of multiple products
Comprehensive analysis, including inorganics and chromatographically challenging compounds
What a Consumer Safety Expert Says About SIFT-MS
"What impressed me most about the Syft technology platform was the real-time detection nature which is really helpful and allows us to investigate real world situations that we wouldn't be able to otherwise. Then, of course, the ability to detect directly from air was huge. That was the primary reason we first got interested in Syft's unique capability to look at that and do it with very high precision." - David Light, CEO / Founder, Valisure.
CEO / Founder, Valisure
Personal Care Product Testing resources
Direct MS Simplifies Analysis of Challenging Compounds
This webcast focuses on case studies that demonstrate simple analysis of chromatographically challenging compounds. Formaldehyde receives special attention, as it is important across a wide range of industries (from environmental to pharmaceutical testing).
SIFT-MS Selected Ion Flow Tube Mass Spectrometry
Learn about direct mass spectrometry by SIFT-MS which provides real-time, quantitative analysis of volatile compounds with trace-level sensitivity. There are also no requirements of chromatography, pre-concentration, or sample prep! SIFT-MS is easy to use and interpret data.
Volatile Compound Analysis: Automated SIFT-MS
SIFT-MS provides direct, rapid sample analysis of volatile organic compounds (VOCs) with no or minimal sample prep required. When coupled with autosampler technology, SIFT-MS yields very high sample throughput (in excess of 100 samples per hour), including for challenging compounds like ammonia, formaldehyde and hydrogen sulfide. Learn how this direct mass spec technology serves a range of industries, from environmental analysis to food testing to pharma.
Routine Analysis 2: Routine Lab Procedures Are Easy to Apply to Direct MS
Learn how you can adopt direct mass spectrometry in your routine analysis workflow. Adaptation of routine procedures and techniques to automated SIFT-MS will be illustrated with case studies applicable to environmental, consumer product and biomedical laboratory testing. In particular, a head-to-head comparison of GC/MS and SIFT-MS for headspace analysis of volatiles in blood plasma will be described.
The SIFT-MS Automation Series: Episode 6 SIFT-MS Automation Past, Present and Future
In this sixth and final episode, Dr Perkins reflects on the automation journey and shares his practical "hot tips" for a wide variety of automated analyses. The webinar (and series!) concludes with a discussion of how automated SIFT-MS is an excellent complementary technique to the conventional laboratory "workhorse" techniques: gas and liquid chromatography.
The SIFT-MS Automation Series: Episode 5 Continuous Headspace Analysis… and Beyond and R&D laboratories.
In this fifth episode, Dr Perkins describes the novel continuous headspace analysis (CHA) technique that he developed to measure stripping of volatiles. (Note: CHA is not to be confused with dynamic headspace analysis!). In addition, Mark describes simple, very high-throughput gas sample bag analysis and touches on other recent developments – including thermal desorption-SIFT-MS.
The SIFT-MS Automation Series: Episode 4 Calibration Approaches for Automated SIFT-MS
In this fourth episode, Dr Perkins describes how simply and rapidly traditional instrument calibration is achieved with the automated SIFT-MS configuration. Traditional calibration approaches have not featured regularly in the SIFT-MS literature due to the widespread use of reliable library-based quantitation. However, calibration is essential for contract testing laboratories, so it is addressed in detail and from a number of different angles in this webinar.
The SIFT-MS Automation Series, Episode 3: Advanced Headspace Methods with SIFT-MS
In this third episode, Dr Perkins describes the application of SIFT-MS to multiple headspace extraction (MHE). You will learn how to determine matrix-independent concentrations from MHE. Furthermore, Dr Perkins describes how the speed of SIFT-MS analysis can be leveraged to accelerate method development for both SIFT-MS and conventional methods – for example, through rapid determination of headspace equilibration times.
The SIFT-MS Automation Series, Episode 2: Accelerate Static Headspace Analysis with SIFT-MS
In this second episode, Dr Perkins provides a practical guide to automated static headspace (SH) analysis with SIFT-MS. You will learn how SH-SIFT-MS can address throughput challenges and simplify analysis of chromatographically challenging species.
The SIFT-MS Automation Series, Episode 1: Why Automate Analysis?
In this first episode, Dr Perkins answers the important question:
Why Automate Analysis?
This webinar introduces the benefits of automation and discusses how they can be applied to SIFT-MS, enabling straightforward adoption by the contract laboratory.
SIMPLE, RAPID ANALYSIS OF PACKAGING FOR VOLATILE MOSH AND MOAH CONTAMINANTS
Headspace-SIFT-MS can screen over 220 samples per day for volatile MOSH and MOAH compounds – nearly seven-fold more samples than the routine liquid and gas chromatography method.
A Sensory Expert Shares His Experience with SIFT-MS
We asked Mike McGinley, President, St. Croix Sensory, Inc. about his experience using SIFT-MS. Hear what he had to say about the speed of analysis and flexibility inherent to Syft's product solutions.
High-Throughput, Quantitative Analysis of Benzene in Personal Care Products using Headspace-SIFT-MS
SIFT-MS provides rapid, sensitive, and robust analysis of benzene and other contaminants in a wide array of commercial products. Integration with a headspace autosampler enables rapid screening of hundreds of samples per day.
A Consumer Safety Expert Shares His Experience with SIFT-MS
We asked David Light, CEO and Founder of Valisure, about his experience using SIFT-MS and how it impacted their dry shampoo safety study.
Rapid Odor Screening of Paperboard Using Static Headspace-SIFT-MS
Automated SIFT-MS analysis coupled with multivariate statistical analysis provides rapid sensory screening of paperboard packaging, overcoming the low sample throughput of sensory panels. The ability to use HS-SIFT-MS to achieve throughput of 12 samples per hour is demonstrated.
Syft Tracer: The Next Generation of Volatile Impurities Analysis for Enhanced Workflows
This app note introduces the next generation of SIFT-MS, Syft TracerTM, which launched at Pittcon 2023. It revolutionizes volatile impurities analysis workflows through unparalleled speed, performance stability, and reproducibility. Learn about how this innovation to real-time trace gas detection outpaces chromatography-based methods in the analysis of challenging analytes such as formaldehyde in a PEG excipient.
SIFT-MS: Quantifying the Volatiles You Smell . . . and the Toxics You Don’t
SIFT-MS has been widely applied to quantitative analysis of a broad range of VOCs in applications from food products to workplace safety to environmental monitoring, and most recently to pharmaceutical testing. This review surveys the applications of SIFT-MS in odor analysis and in workplace, environmental and consumer protection, with a particular focus on the complementarity of this real-time mass spectrometry analyzer to sensor technology and conventional laboratory techniques—in particular, gas chromatography–mass spectrometry (GC/MS).
The Latest Innovation of Real-Time, High-Throughput Volatile Impurities Analysis by SIFT-MS
Join us for this webinar to learn about Syft Tracer, the latest advancement of real-time, trace gas analysis by SIFT-MS which launched at Pittcon 2023. Hear how the recent product innovations unlock analytical bottlenecks and enable faster decisions to be made in critical process steps.
High Throughput SIFT-MS Analysis of Formaldehyde in Fragrances Using the Method of Standard Additions
This application note describes high throughput analysis of formaldehyde in fragrances that utilizes a method of standard additions to overcome matrix effects from variable headspace compositions of the samples tested. SIFT-MS delivers >2X faster time to data with up to 5X greater throughput than chromatographic methods.
Application Brief: Revolutionary Workflows for Volatile Impurities Analysis
This application brief summarizes a scenario relevant to contract research organization (CRO) and contract drug manufacturing organization (CDMO) laboratories where multiple volatile impurity methods need to be conducted in short runs. Five analyses are considered that can be handled by one Syft Tracer but require multiple legacy, chromatography instruments. For these analyses, SIFT-MS reports the first quantitative results 2- to 12-fold faster, and has sample throughputs 3- to 17-fold higher than the conventional procedures.
Headspace-SIFT-MS: Flexibility that Revolutionizes Workflows for Diverse Samples
The characteristic flexibility, stability, high throughput, and fast time to data of the Syft Tracer next-gen SIFT-MS instrument apply across multiple headspace approaches for diverse matrices. This application note briefly summarizes the use of (1) dissolution, (2) multiple headspace extraction (MHE), and (3) the method of standard additions, then provides a guide for identifying the appropriate headspace approach for various matrices.
Revolutionizing Volatile Impurities Analysis Through Next Gen SIFT-MS
This E-book describes how next gen SIFT-MS enables rapid, continuous screening of toxic volatile impurities in pharmaceutical and consumer products. This advancement to SIFT-MS delivers trace-level detection sensitivity, unparalleled performance stability, superior selectivity, and highly reproducible, quantitative data. Never miss a contamination event again.
Fast, Simple Quantitation of Odors by SIFT-MS
In this on-demand webinar, Michael McGinley, President, St. Croix Sensory, describes how SIFT-MS has advanced their ability to rapidly perform odor analysis. A variety of SIFT-MS-based odor applications correlated with conventional sensory panel assessment are presented. Learn how Syft is Simply. Faster. for the analysis of odor compounds.
Improved MHE-SIFT-MS Workflows - Concentration Independent MHE Calibration
This application note investigates concentration dependence of MHE calibration in sample matrix. Across the full range of analytes investigated in this study, MHE calibration holds for at least one order of magnitude change in sample concentration. For analytes in the C7–C9 range, the MHE calibration applies over two orders of magnitude analyte concentration. These results mean that the MHE workflow can be applied to a wider range of samples in the matrix, further reducing calibration demand.
High-Throughput Analysis of Polymers for Benzene and Volatile MOSH and MOAH Residues
This application note describes the utility of SIFT-MS in pre-screening polymer packaging materials for volatile MOSH and MOAH compounds. Automated SIFT-MS can characterize 12 high-density polyethylene (HDPE) and polypropylene (PP) samples per hour, or 220 / day. Headspace-SIFT-MS readily analyzes benzene at high sensitivity as part of the same analysis.
EtO and Acetaldehyde in Polysorbate 80: Rapid Quantitative Analysis Using SIFT-MS
This study evaluates a headspace-SIFT-MS approach for Polysorbate 80 products from multiple suppliers and evaluates ethylene oxide and acetaldehyde recoveries. Results confirm that the headspace-SIFT-MS procedure reliably quantifies these analytes without requiring purification of Polysorbate 80 for matrix-matching the calibration standard. Hence, headspace-SIFT-MS analysis of ethylene oxide and acetaldehyde can revolutionize existing workflows.
SIFT-MS Analysis of Benzene in Sunscreens and VOC Exposure
This application note summarizes the SIFT-MS results obtained in a study of exposure to VOCs from 26 retail sunscreen products – both VOCs intended as ingredients and those present as contaminants. The commercial products varied widely in VOC content and hence user exposure. Several products contained benzene contamination that was readily quantified using dynamic headspace-SIFT-MS analysis.
Quantitative Impurities Analysis of Consumer Products Using SIFT-MS
This webinar features David Light of Valisure and includes case studies that demonstrate how SIFT-MS provides faster and more accurate analysis of volatile impurities in consumer products. Learn how benzene has been detected in commercial products like dry shampoo and sunscreens.