Biomedical
SIFT-MS has diverse biomedical research applications from breath research to headspace analysis of microbes, body fluids and tissues.
Volatile compounds, individually or as a profile, can indicate health status of humans and other organisms.
SIFT-MS speeds up analysis time in both breath research and microbial metabolic process profiling. Breath research data can be used for population screening and to monitor temporal changes in breath volatiles.
High-sensitivity, direct analysis of diverse breath biomarkers
SIFT-MS provides rapid, high-sensitivity analysis of VOCs and inorganic gases on breath with no sample preparation and no compound discrimination, making it ideal for breath research applications.
Benefits include:
- Real-time analysis of individual breath exhalations
- Analytical results unaffected by sample humidity – no sample drying is required
- Very wide linear and dynamic range
- Flexibility – analyze directly or via sampling media, such as sampling bags
Applications of SIFT-MS-based breath analysis include:
- Disease marker screening
- Kidney medicine
- Non-invasive diabetes screening
- Respiratory medicine
- Intensive care medicine
- Monitoring anesthetics during surgery
Single breath SIFT-MS analysis for hydrogen cyanide (gray) and hydrogen sulfide (black).
Find out more about SIFT-MS capabilities in Biomedical
Developing Non-Invasive Breath Tests for Upper Gastrointestinal Tract Cancers
Part 4: Biomedical and Pharma
Online Demonstration: Pharmaceutical Applications
Syft App Talks #22. Closed System Transfer Devices – Performance Testing Using SIFT-MS
Halitosis Diagnosis and Control Using SIFT-MS
Syft App Talks #19. Comparing SIFT-MS and GC/MS in a Biomedical Context: A Solvent and Its Metabolite in Plasma
Syft Application Talks 12: Development of Breath Test for Esophageal Cancer
Syft Application Talks #11. Design Requirement for Breath Clinical Studies
Syft Tracer: The Next Generation of Volatile Impurities Analysis for Enhanced Workflows
This app note introduces the next generation of SIFT-MS, Syft TracerTM, which launched at Pittcon 2023. It revolutionizes volatile impurities analysis workflows through unparalleled speed, performance stability, and reproducibility. Learn about how this innovation to real-time trace gas detection outpaces chromatography-based methods in the analysis of challenging analytes such as formaldehyde in a PEG excipient.
Head to Head Comparison of Class 2A And 2B Residual Solvents Analysis Using Sift-MS And GC-FID
This application note describes head-to-head comparison of GC-FID and SIFT-MS analyses of Class 2A and 2B residual solvents. The techniques perform similarly for linearity and repeatability, but SIFT-MS provides superior performance for accuracy and recovery. Furthermore, SIFT-MS provides greater than 11-fold increase in sample throughput and significantly reduces the time taken to report quantitative results (over six times faster for a full calibration set).
Recent developments and applications of selected ion flow tube mass spectrometry (SIFT‐MS)
SIFT‐MS is now recognized as the most versatile analytical technique for the identification and quantification of trace gases down to the parts‐per‐trillion by volume, pptv, range. This statement is supported by the wide reach of its applications, from real‐time analysis, obviating sample collection of very humid exhaled breath, to its adoption in industrial scenarios for air quality monitoring. This review touches on the recent extensions to the underpinning ion chemistry kinetics library and the alternative challenge of using nitrogen carrier gas instead of helium.
The Latest Innovation of Real-Time, High-Throughput Volatile Impurities Analysis by SIFT-MS
Join us for this webinar to learn about Syft Tracer, the latest advancement of real-time, trace gas analysis by SIFT-MS which launched at Pittcon 2023. Hear how the recent product innovations unlock analytical bottlenecks and enable faster decisions to be made in critical process steps.