Biomedical

SIFT-MS has diverse biomedical research applications from breath research to headspace analysis of microbes, body fluids and tissues.

This brochure outlines several SIFT-MS based breath and medical research solutions provided by Syft Technologies.  Real-time results are provided to diverse breath and microbial research applications, including non-invasive population screening, breath VOCs monitoring, and the rapid identification of microorganisms by their VOC fingerprints.

In this webinar, we describe:

• Why early detection of gastro-esophageal cancers is so challenging
• Research utilizing SIFT-MS, with potential screening applications
• Future external validation work using Thermal Desorption-SIFT-MS

In this webinar, we describe the wide range of biomedical and pharmaceutical applications in which SIFT-MS solves difficult analytical challenges.  These include:

• Breath research, for which there is a significant academic literature
• Analysis of body fluid headspace
• Microbial VOC analysis
• Emerging small-molecule applications for the pharma industry

This workshop includes:

• An overview of the current industries that are using SIFT-MS and the companies that are benefiting from it
• What distinguishes SIFT-MS from other mass spectrometry techniques
• Where and how SIFT-MS applies in the pharmaceutical industry
• Live demonstrations: using SIFT-MS to analyze various samples
• Breakdown of sample analysis, including Syft Technologies' custom software that displays data in real-time.

Dr. Mark Perkins (Anatune Limited, UK) and Alan Wilkinson (Biopharma Stability Testing Laboratory, UK) collaborated to evaluate SIFT-MS for determination of CSTDs using protocols previously developed by NIOSH (USA). Using propylene glycol methyl ether (PGME) as a surrogate, SIFT-MS detects sub-microlitre volume leaks from these devices.

Join this Syft Application Talk presented by Mark Perkins to learn more!

We have used SIFT-MS for the analysis of volatiles from in vitro biofilm cultures inoculated with human tongue-derived biofilm prior to and following treatment with anti-malodor formulations. We have also used the SIFT-MS in clinical trial settings to measure the efficacy of a wide range of oral care products. This webinar will present the application of the SIFT-MS in halitosis research including current and future trends.

Self-poisoning with professional agricultural pesticide products is responsible for about 20% of global suicide.  Fast detection could aid earlier identification of pesticide poisoning thus allowing faster intervention, reducing mortality.  We compare analysis by both automated headspace GC/MS and SIFT-MS.  The results obtained showed a four-fold increase in throughput for SIFT-MS over GC/MS.

Who could be better qualified to explain the need for improved outcomes for people with upper gastrointestinal (GI) cancers than renowned surgeon, researcher, and head of Imperial College’s Department Surgery and Cancer, Professor George Hanna? Prof. Hanna joined us at the 2020 European Online SIFT-MS User Meeting to describe his group’s breath research targeted at identifying upper GI cancers earlier. His work is reviewed and upcoming external validation studies are outlined.

SIFT-MS’s high-throughput analysis of breath (whether directly, from sampling bags, or from thermal desorption tubes) means that it is an ideal instrument for breath research. In this presentation, Professor Hanna summarizes what he and his research team have implemented in terms of best practices based on years of breath research.

This app note introduces the next generation of SIFT-MS, Syft Tracer^TM, which launched at Pittcon 2023.  It revolutionizes volatile impurities analysis workflows through unparalleled speed, performance stability, and reproducibility.  Learn about how this innovation to real-time trace gas detection outpaces chromatography-based methods in the analysis of challenging analytes such as formaldehyde in a PEG excipient.

This application note describes head-to-head comparison of GC-FID and SIFT-MS analyses of Class 2A and 2B residual solvents. The techniques perform similarly for linearity and repeatability, but SIFT-MS provides superior performance for accuracy and recovery. Furthermore, SIFT-MS provides greater than 11-fold increase in sample throughput and significantly reduces the time taken to report quantitative results (over six times faster for a full calibration set).

SIFT‐MS is now recognized as the most versatile analytical technique for the identification and quantification of trace gases down to the parts‐per‐trillion by volume, pptv, range. This statement is supported by the wide reach of its applications, from real‐time analysis, obviating sample collection of very humid exhaled breath, to its adoption in industrial scenarios for air quality monitoring. This review touches on the recent extensions to the underpinning ion chemistry kinetics library and the alternative challenge of using nitrogen carrier gas instead of helium. 

Join us for this webinar to learn about Syft Tracer, the latest advancement of real-time, trace gas analysis by SIFT-MS which launched at Pittcon 2023. Hear how the recent product innovations unlock analytical bottlenecks and enable faster decisions to be made in critical process steps.

Syft Tracer^TM is the latest advancement in real-time, direct injection mass spectrometry (MS) built to solve the most difficult analytical challenges faced within a variety of industries and applications.  This advancement to SIFT-MS delivers trace-level detection sensitivity, unparalleled performance stability, superior selectivity, and highly reproducible, quantitative data.  Syft Tracer is optimized for high-throughput environments where continuous operation is the standard.  Never miss a product or environmental contamination event again.

This application note describes how the efficiency of a MHE workflow can be significantly improved for MHE-SIFT-MS due to the stability of the technique. Formaldehyde impurity is analyzed easily and quantitatively in Gelucire excipient with this improved approach.  The time-to-result is reduced to 85 minutes for this system – six-fold faster than the conventional MHE-SIFT-MS approach.  Quantitative analysis is achieved at the throughput of 220 samples/day.

This application note describes a scenario in which Syft Tracer^TM analyzed the same amount of samples in 9 hours that it took 5 chromatographic systems 24 hours to complete and still had capacity to spare. Next-gen SIFT-MS provides rapid, chromatography-free workflows which revolutionize volatile compound analysis. 

This webinar demonstrates how the new, automated Syft Tracer^TM SIFT-MS platform provides a comprehensive solution to workflow challenges and can replace multiple chromatographic systems.  Learn about how combining SIFT-MS with automation provides a very flexible and high throughput solution for screening volatile impurities in pharmaceutical and consumer safety applications, revolutionizing workflows.

This E-book describes how next gen SIFT-MS enables rapid, continuous screening of toxic volatile impurities in pharmaceutical and consumer products. This advancement to SIFT-MS delivers trace-level detection sensitivity, unparalleled performance stability, superior selectivity, and highly reproducible, quantitative data. Never miss a contamination event again. 

This application note investigates concentration dependence of MHE calibration in sample matrix.  Across the full range of analytes investigated in this study, MHE calibration holds for at least one order of magnitude change in sample concentration.  For analytes in the C7–C9 range, the MHE calibration applies over two orders of magnitude analyte concentration. These results mean that the MHE workflow can be applied to a wider range of samples in the matrix, further reducing calibration demand.

Download this cover story article in the June 2024 issue of Dairy which examines the effectiveness of yogurt in deodorizing garlic breath.  Learn how SIFT-MS was used in breath (in vivo) and headspace (in vitro) analyses of garlic sulfur volatiles to determine the effect of yogurt on sulfur garlic volatiles.

This whitepaper highlights the exceptional reproducibility of Syft Technologies' SIFT-MS instruments, showcasing fleet performance across legacy and latest-generation platforms. By comparing standardized analytical methods on multiple instruments, it demonstrates high consistency in trace gas quantitation with 95% confidence intervals below 21% for the Syft Tracer and 38% for legacy devices. The findings emphasize Syft's commitment to advancing reliable, real-time analysis solutions for diverse applications.

This technical note explores automated analytical approaches using SIFT-MS. Building on Part 1, it covers applications such as static headspace analysis (SHA), multiple headspace extraction (MHE), the method of standard additions (MoSA), and continuous headspace analysis (CHA). Additional techniques include thermal desorption, solid-phase microextraction, and gas sampling bags, offering rapid and robust analysis of volatile organic compounds (VOCs). Ideal for laboratories seeking efficient workflows, SIFT-MS automation enhances throughput and accuracy across diverse sample types.

This technical note highlights the significant workflow advantages of automating SIFT-MS. By comparing SIFT-MS with conventional GC methods, it demonstrates how faster analysis times, reduced calibration demands, and simplified processes enhance productivity. The document explores the economic and operational benefits across various applications, including headspace analysis, multiple headspace extraction (MHE), and method of standard additions (MoSA). Ideal for laboratories seeking improved throughput and streamlined operations, this guide showcases the efficiency gains achievable with automated SIFT-MS systems.

This whitepaper showcases how SIFT-MS eliminates chromatography to deliver real-time, high-sensitivity VOC analysis with unmatched speed and simplicity. Learn how ditching columns unlocks faster workflows, reduced maintenance, and greater sustainability across labs and process environments.

Discover how automated SIFT-MS enables fast, sustainable volatiles analysis by eliminating complex sample prep and reducing environmental impact. This whitepaper explores real-world workflows and evaluates SIFT-MS against modern green chemistry standards using the White Analytical Chemistry framework.

Syft solutions eliminate the delays and complexity of conventional methods, empowering scientists and industries to make confident decisions on the spot. Delivering results across a wide range of applications including mobile environmental monitoring, food, flavor, and fragrance evaluation, semiconductor manufacturing, and pharmaceutical quality assurance, Syft brings the lab directly to your process by enabling rapid, automated, and direct analysis of VOCs and other trace gases, Syft helps customers worldwide improve productivity, strengthen compliance, and unlock new insights across R&D, manufacturing, and quality control.