Biomedical

SIFT-MS has diverse biomedical research applications from breath research to headspace analysis of microbes, body fluids and tissues.

Volatile compounds, individually or as a profilecan indicate health status of humans and other organisms.

SIFT-MS speeds up analysis time in both breath research and microbial metabolic process profiling.  Breath research data can be used for population screening and to monitor temporal changes in breath volatiles.

High-sensitivity, direct analysis of diverse breath biomarkers

SIFT-MS provides rapid, high-sensitivity analysis of VOCs and inorganic gases on breath with no sample preparation and no compound discrimination, making it ideal for breath research applications.

Benefits include:

  • Real-time analysis of individual breath exhalations
  • Analytical results unaffected by sample humidity – no sample drying is required
  • Very wide linear and dynamic range
  • Flexibility – analyze directly or via sampling media, such as sampling bags

Applications of SIFT-MS-based breath analysis include:

  • Disease marker screening
  • Kidney medicine
  • Non-invasive diabetes screening
  • Respiratory medicine
  • Intensive care medicine
  • Monitoring anesthetics during surgery
Fig 3 not good res

Single breath SIFT-MS analysis for hydrogen cyanide (gray) and hydrogen sulfide (black).

Find out more about SIFT-MS capabilities in Biomedical

Webinar

Developing Non-Invasive Breath Tests for Upper Gastrointestinal Tract Cancers

George Hanna, Head of Department of Surgery and Cancer, along with our own Vaughan Langford, describes the potential of SIFT-MS for early detection of gastro-esophageal cancers In the early stages, cancers of the upper gastrointestinal tract exhibit symptoms that are identical to benign conditions.
Watch
Webinar

Part 4: Biomedical and Pharma

In this webinar, we continue our seven-episode series, which outlines the diverse applications of the SIFT-MS technique.
Watch
Webinar

Online Demonstration: Pharmaceutical Applications

This online demonstration showcases the pharmaceutical industry applications of SIFT-MS. SIFT-MS is a technique that utilizes chemical ionization to quantify volatiles and inorganic gases in samples.
Watch
Webinar

Syft App Talks #22. Closed System Transfer Devices – Performance Testing Using SIFT-MS

Closed System Transfer Devices – Performance Testing Using SIFT-MS Dr Mark Perkins, Senior Applications Chemist, Anatune Limited, United Kingdom Leakage from closed system transfer devices (CSTDs) can pose significant health and safety risks to medical professionals administering pharmaceuticals such as anti-cancer drugs.
Watch
Webinar

Halitosis Diagnosis and Control Using SIFT-MS

Halitosis or oral malodor is a common condition affecting about one third of the population worldwide.
Watch
Webinar

Syft App Talks #19. Comparing SIFT-MS and GC/MS in a Biomedical Context: A Solvent and Its Metabolite in Plasma

Comparing SIFT-MS and GC/MS in a Biomedical Context: A Solvent and Its Metabolite in Plasma Dr Colin Hastie, Anatune, United Kingdom Self-poisoning with professional agricultural pesticide products is responsible for about 20% of global suicide.
Watch
Webinar

Syft Application Talks 12: Development of Breath Test for Esophageal Cancer

Development of Breath Test for Esophageal Cancer Prof.
Watch
Webinar

Syft Application Talks #11. Design Requirement for Breath Clinical Studies

Design Requirement for Breath Clinical Studies Prof.
Watch
Application Note

Syft Tracer: The Next Generation of Volatile Impurities Analysis for Enhanced Workflows

This app note introduces the next generation of SIFT-MS, Syft TracerTM, which launched at Pittcon 2023.  It revolutionizes volatile impurities analysis workflows through unparalleled speed, performance stability, and reproducibility.  Learn about how this innovation to real-time trace gas detection outpaces chromatography-based methods in the analysis of challenging analytes such as formaldehyde in a PEG excipient.

Download Download
Application Note

Head to Head Comparison of Class 2A And 2B Residual Solvents Analysis Using Sift-MS And GC-FID

This application note describes head-to-head comparison of GC-FID and SIFT-MS analyses of Class 2A and 2B residual solvents. The techniques perform similarly for linearity and repeatability, but SIFT-MS provides superior performance for accuracy and recovery. Furthermore, SIFT-MS provides greater than 11-fold increase in sample throughput and significantly reduces the time taken to report quantitative results (over six times faster for a full calibration set).

Download Download
Document

Recent developments and applications of selected ion flow tube mass spectrometry (SIFT‐MS)

SIFT‐MS is now recognized as the most versatile analytical technique for the identification and quantification of trace gases down to the parts‐per‐trillion by volume, pptv, range. This statement is supported by the wide reach of its applications, from real‐time analysis, obviating sample collection of very humid exhaled breath, to its adoption in industrial scenarios for air quality monitoring. This review touches on the recent extensions to the underpinning ion chemistry kinetics library and the alternative challenge of using nitrogen carrier gas instead of helium. 

Download Download
Webinar

The Latest Innovation of Real-Time, High-Throughput Volatile Impurities Analysis by SIFT-MS

Join us for this webinar to learn about Syft Tracer, the latest advancement of real-time, trace gas analysis by SIFT-MS which launched at Pittcon 2023. Hear how the recent product innovations unlock analytical bottlenecks and enable faster decisions to be made in critical process steps.

Watch